141-12-8, name is (Z)-3,7-Dimethylocta-2,6-dien-1-yl acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of (Z)-3,7-Dimethylocta-2,6-dien-1-yl acetate
General procedure: To a solution of the geranyl derivative (1.0 equiv) in acetonitrile(0.07 M) cooled to 0 C, PIFA (1.1 equiv) was added. Asolution of tetra-n-butylammonium bromide (1.1 equiv) inacetonitrile (0.07 M) was then added dropwise over 5 min.After stirring for 10 min, the reaction mixture was diluted withEtOAc, saturated aqueous Na2S2O3 solution was added and thelayers were separated. The aqueous layer was extracted twicewith EtOAc. The combined organic extracts were washed withbrine, dried over MgSO4, filtered and concentrated underreduced pressure before purification by flash chromatography.
The synthetic route of 141-12-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Peilleron, Laure; Grayfer, Tatyana D.; Dubois, Joelle; Dodd, Robert H.; Cariou, Kevin; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1103 – 1111;,
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