These common heterocyclic compound, 2033-24-1, name is 2,2-Dimethyl-1,3-dioxane-4,6-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: esters-buliding-blocks
General procedure: Method A: Adapted from the procedure of Srensen et al.14 To a solution of Meldrum?s acid (1equiv) in dichloromethane at 0C was added pyridine (2equiv) drop wise, and the resulting solution was stirred for 15min. The corresponding acid chloride (1equiv) was added to this reaction mixture. Thereafter, the reaction was stirred for 1.5h at 0C, and for an additional 1.5h at room temperature. The reaction was quenched with 2M hydrochloric acid, and extracted with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography using a gradient from 5% to 10% ethyl acetate in hexane, 1% acetic acid to yield acyl Meldrum?s acids (11a-e, j, l, p).
The synthetic route of 2,2-Dimethyl-1,3-dioxane-4,6-dione has been constantly updated, and we look forward to future research findings.
Reference:
Article; Verma, Astha; Wong, Dawn M.; Islam, Rafique; Tong, Fan; Ghavami, Maryam; Mutunga, James M.; Slebodnick, Carla; Li, Jianyong; Viayna, Elisabet; Lam, Polo C.-H.; Totrov, Maxim M.; Bloomquist, Jeffrey R.; Carlier, Paul R.; Bioorganic and Medicinal Chemistry; vol. 23; 6; (2015); p. 1321 – 1340;,
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