New learning discoveries about 89-91-8

Synthetic Route of 89-91-8,Some common heterocyclic compound, 89-91-8, name is Methyl 2,2-dimethoxyacetate, molecular formula is C5H10O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthetic Route of 89-91-8,Some common heterocyclic compound, 89-91-8, name is Methyl 2,2-dimethoxyacetate, molecular formula is C5H10O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step F; 5-Bromo-6-ethyl-N*2*-isopropyl-pyridine-2, 3-diamine (1 g) is dissolved in diethoxymethylacetate (4 mL) and is heated at 120 C for 90 min. After cooling to RT the mixture is directly purified by flash column chromatography on silica gel to give 6-bromo-5- ETHYL-3-ISOPROPYL-3H-IMIDAZO [4,5-b] pyridine as colorless oil. Rf (hexane: EtOAc = 2: 1) = 0.32

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2,2-dimethoxyacetate, its application will become more common.

Reference:
Patent; NEUROGEN CORPORATION; AVENTIS PHARMACEUTICALS INC.; WO2005/23806; (2005); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics