Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18595-18-1, name is Methyl 3-amino-4-methylbenzoate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 3-amino-4-methylbenzoate
Step 1: synthesis of methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate (108) A solution of 7-aminothieno[2,3-b]pyrazine-6-carboxylic acid (8) (2.56 mmol, 500 mg), methyl 3-amino-4-methylbenzoate (2.56 mmol, 423 mg), TBTU (3.84 mmol, 1234 mg) and DIPEA (7.68 mmol, 1.260 mL in DMF (10 mL) was stirred 2 days at 80 C. The brown solution was poured into citric acid solution, the precipitation was filtered of and washed with water. Purification by chromatography (0-40% ethyl acetate in CH2Cl2) gave methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate 108 (143 mg, 15%). (m/z)=343 (M+H)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Folmer, Brigitte Johanna Bernita; Man, de Adrianus Petrus Antonius; Gernette, Elisabeth Sophia; Corte Real Goncalves Azevedo, Rita; Ibrahim, Hemen; US2013/79341; (2013); A1;,
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