Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1117-71-1, name is Methyl 4-bromobut-2-enoate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C5H7BrO2
The (E) -4- bromo crotonate 6g (33.5mmol) was dissolved in THF (60ml) cooled to to 0 ,Under the protection of N2 was added dropwise lithium hydroxide monohydrate 1.83g (43.6mmol) in water(20mL). After the dropping 15min, 0 kept stirred 3h. And then cold water 150ml200ml of petroleum ether was added to the system to continue stirring 10min at 0 . Separating the aqueous phase, at 0 PH adjusted with concentrated hydrochloric acid to 1, with dichloromethane (80mlx3) and extracted. The combined organicPhase was dried over anhydrous sodium sulfate and concentrated to give compound X, a yellow solid 4.5g, 82% yield.In the E-4- mixed with X-bromo crotonic acid and a drop of DMF in DCM (3ml) was added dropwise a solution of oxalylChlorine (0.025g, 1.96mmol). After the dropwise addition, stirring was raised to room temperature for 1h. Completion of the reaction,The solvent was concentrated to afford the intermediate (E) -4- bromo-2-enoyl chloride III, without further treatment,It was used directly in the next reaction.
According to the analysis of related databases, 1117-71-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chengdu Zepletech Biological Pharmaceutical Co., Ltd.; Wang, Kangmin; Chen, Wei; Zhao, Gang; Liu, Jifeng; Pu, Lin; (22 pag.)CN105669521; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics