Application of 176694-36-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 176694-36-3, name is Methyl 4-fluoro-3-(trifluoromethyl)benzoate, A new synthetic method of this compound is introduced below., Computed Properties of C9H6F4O2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 176694-36-3, name is Methyl 4-fluoro-3-(trifluoromethyl)benzoate, A new synthetic method of this compound is introduced below., Computed Properties of C9H6F4O2

To a solution of the crude methyl ester in DMF (5 mL) was added octane- 1 -thiol (0.87 mL, 5 mmol) and Cs2CCh (2.44g, 7.5 mmol). The reaction mixture was stirred at 600C for 1 h, concentrated, quenched with NH4CI, extracted with EtOAc. The organics was dried over Na2SO4, concentrated under reduced pressure to leave the crude methyl 4-(octylthio)-3-(trifluoromethyl)benzoate 2a. MS (ESI, M+H+) = 349.0

The synthetic route of 176694-36-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRAECIS PHARMACEUTICALS INCORPORATED; WO2008/16692; (2008); A2;,
Ester – Wikipedia,
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