Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35120-18-4, name is Ethyl 1-bromocyclobutanecarboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 1-bromocyclobutanecarboxylate
General procedure: A mixture of thiones or thiol 5a-5q or 5ha-5hi (60 mmol), bromoacetates BrCH2CO2Me,(CH3)2CBrCO2Et or ethyl 1-bromocyclobutanecarboxylate (80 mmol) and K2CO3 (16.59 g, 120 mmol)in a suitable solvent (200 mL; acetone for 5a-5b or DMF for the others) was stirred at a temperaturespecified in Schemes 1-5 until the completion of reaction as indicated by TLC analysis (typicallywithin 12 h). On cooling to room temperature (if necessary), for 5a-5b: the reaction mixture wasfiltered off and the filtrate was evaporated on a rotary evaporator to give a residue, which waspurified by column chromatography to afford 6a-6b; for the others: the reaction mixture was pouredinto ice-water (300 mL), and the resulting mixture was extracted with CH2Cl2 (100 mL × 3). Thecombined extracts were washed with 5% brine (100 mL × 5), dried (Na2SO4) and evaporated on arotary evaporator to afford the crude product as a residue, which was purified by columnchromatography to yield the pure product 6c-6x or 6ha-6hi.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Cai, Wenqing; Wu, Jingwei; Liu, Wei; Xie, Yafei; Liu, Yuqiang; Zhang, Shuo; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Molecules; vol. 23; 2; (2018);,
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