Application of 3196-15-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3196-15-4, name is Methyl 2-bromobutyrate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 4: methyl 2-[2-(4-methylbenzoylimino)-6-(phenylcarbamoyl)benzo[d]thiazol-3(2H)-yl]butanoate To a solution of 2-(4-methylbenzamido)-N-phenylbenzo[d]thiazol-6-carboxamide (200 mg, 0.52 mmol) prepared in Step 3 in N,N-dimethylformamide (2.0 mL) was added dropwise potassium carbonate (216 mg, 1.56 mmol) and methyl 2-bromobutyrate (90 uL, 0.78 mmol). The reaction mixture was refluxed under stirring at 80 C. overnight. The reaction mixture was quenched with water and then extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered, and then evaporated. The residue was purified with silica gel column chromatography (n-hexaneethyl acetate=2/1, v/v) to give 200 mg of the titled compound as a white solid (Yield: 79%). 1H NMR (CDCl3, 400 MHz) delta 8.23 (s, 1H), 8.17 (d, 2H), 7.97 (d, 1H), 7.88 (s, 1H), 7.65 (d, 2H), 7.34-7.41 (m, 3H), 7.28 (d, 2H), 7.18 (t, 1H), 5.63 (m, 1H), 3.68 (s, 3H), 2.46-2.57 (m, 2H), 2.42 (s, 3H), 0.92 (t, 3H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromobutyrate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; YUHAN CORPORATION; Hur, Youn; Kim, Dong-Hyun; Kim, Eun-Kyung; Park, Jin-Hwi; Joo, Jae-Eun; Kang, Ho-Woong; Oh, Se-Woong; Kim, Dong-Kyun; Ahn, Kyoung-Kyu; US2015/11528; (2015); A1;,
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