Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3196-15-4, name is Methyl 2-bromobutyrate, A new synthetic method of this compound is introduced below., Formula: C5H9BrO2
Weighed 2,4-dichlorophenol (815mg, 5mmol) in 100mL round bottom flask was added anhydrous potassium carbonate (1.38g, 10.0mmol, 2eq), acetone (30 mL) and 2-bromo-butyric acid methyl ester ( 995.6mg, 5.5mmol, 1.1eq), was heated under reflux for 12 hours.The reaction was cooled to room temperature, the solid was removed by suction filtration, and the filtrate was evaporated to dryness after the addition of water (30 mL), extracted with ethyl acetate (50mL × 3), combined extracts were washed with water (20mL × 2) and saturated brine (20 mL ) was washed, dried over anhydrous sodium sulfate, filtered and concentrated, the crude product was purified by silica gel column chromatography [V (ethyl acetate) :V (petroleum ether) = 1: 8] to give 1.22g, 93% yield.1HNMR (400MHz, CDCl3)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Changzhou University; Chen, Xi; Liang, Cuirong; Yang, Qinghong; Ren, Jie; Jin, Guihua; Huang, Qianhui; Xu, Yuanyuan; Hu, Kun; (32 pag.)CN105440020; (2016); A;,
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