In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 150726-89-9, name is Dimethyl 2-(2-methoxyphenoxy)malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 150726-89-9
d) Na (2.3 g) was dissolved in methanol (40 ml) and 2-(3-methoxy-phenyl)-acetamidine hydrochloride (10 g) and (2-methoxyphenoxy)-malonic acid dimethyl ester (12.67 g) were added in succession at room temperature. The mixture was stirred for 5 hours at room temperature, concentrated in a rotary evaporator and the crude product was added to water. The aqueous phase was washed with ethyl acetate, adjusted to pH 1 and the precipitated crystals were sucked off and dried under a high vacuum. There was thus obtained 2-(3-methoxy-benzyl)-5-(2-methoxy-phenoxy)-pyrimidine-4,6-diol as beige crystals. MS: 354 (M)
The synthetic route of 150726-89-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hoffmann-La Roche Inc.; US5837708; (1998); A;,
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