14064-10-9, name is Diethyl 2-chloromalonate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Diethyl 2-chloromalonate
General procedure: To a suspension of CsF (183 mg, 1.20 mmol) in DMF (2.0 mL) was added Et2Zn (1.0 M in toluene,200 muL, 0.20 mmol) under argon atmosphere at ?40 °C. After being stirred at the same temperature for5 min, diethyl alpha-chloromalonate 4a (32 muL, 0.20 mmol) and 3-methoxy-2-(trimethylsilyl)phenyltriflate (1, 63 muL, 0.24 mmol) were added to the reaction mixture. After being stirred at ?40 °C toroom temperature for 12 h, silica gel (0.5 g) was added to the reaction mixture, and then it wasconcentrated under reduced pressure. Purification of the residue by flash silica gel columnchromatography (EtOAc/hexane = 1:20?1:4) afforded dihydrobenzofuran 7a (58.0 mg, 86percent). Undersimilar reaction conditions, dihydrobenzofurans 7b and 11 were synthesized. Products 8a, 12 and 13were also formed.#10;#10;
The synthetic route of 14064-10-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yoshioka, Eito; Kohtani, Shigeru; Miyabe, Hideto; Molecules; vol. 19; 1; (2014); p. 863 – 880;,
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