Related Products of 4224-69-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4224-69-5 as follows.
Cyclopentylamine (5.79 mL, 58.7 mmol, 3.00 eq) and triethylamine (2.73 mL, 19.6 mL, 1.00 eq) were added to DCM (98 mL) and the reaction was cooled to 0 C. Methyl 2-(bromomethyl)acrylate (2.35 mL, 19.6 mmol, 1.00 eq) in DCM (48 mL) was added dropwise. Following addition the reaction was stirred for an additional 30 minutes at 0 C. Water was added and the layers separated. The aqueous layer was extracted with an additional portion of DCM and the combined organics were dried (MgS04), filtered and concentrated in vacuo. Purification by flash chromatography on silica gel using 0- 60% DCM/MeOH/NH4OH (89: 10: 1) afforded 1.19 g (33%) of the title compound as a clear oil: 1H MR (400 MHz, DMSO-d6) 3 6.10 (s, 1H), 5.79 (s, 1H), 3.67 (s, 3H), 3.65 (d, J= 5.9 Hz, 1H), 3.56 (d, J= 15.1 Hz, 1H), 3.21 (d, J= 7.4 Hz, 1H), 2.98 (p, J= 6.2 Hz, 1H), 1.72-1.22 (m, 8H); ES-MS [M+l]+: 184.4.
According to the analysis of related databases, 4224-69-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; NISWENDER, Kevin; (90 pag.)WO2017/117556; (2017); A1;,
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