Brief introduction of 314298-22-1

Reference of 314298-22-1,Some common heterocyclic compound, 314298-22-1, name is Methyl 5-bromo-4-fluoro-2-methoxybenzoate, molecular formula is C9H8BrFO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference of 314298-22-1,Some common heterocyclic compound, 314298-22-1, name is Methyl 5-bromo-4-fluoro-2-methoxybenzoate, molecular formula is C9H8BrFO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Cool in ice a solution of the product of Step 2 (1.15 g, 4.1 mmol) in THF (15 ml). Add dropwise BH3.Me2S (2.0M in THF, 4.2 ml, 8.4 mmol). Heat at 60 C. 18 h, allow to cool, quench with methanol, concentrate and partition with EtOAc and sat. NaHCO3. Wash with water, then brine, dry (MgSO4) and concentrate to obtain the alcohol as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-bromo-4-fluoro-2-methoxybenzoate, its application will become more common.

Reference:
Patent; Schering Corporation; US2005/239795; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics