Related Products of 57486-69-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57486-69-8 as follows.
Methyl o-bromophenylacetate (4.6g, 0.02mol),2,6-Dichloroaniline (16.4 g, 0.1 mol),Copper iodide (1.92g, 0.01mol),Anhydrous potassium carbonate (11.2g, 0.08mol) and xylene (100ml) were placed in a dry reaction flask.Under nitrogen protection,The reaction was stirred at 200C for 50 hours under reflux.Activated carbon is added after the reaction is completed.Hot filter,The filtrate was concentrated to dryness under reduced pressure.The residue is dissolved in methanol,Crystallize in ice water bath,Suction filtrationWhite solid 5.50g (diclofenac methyl ester) was dried,Yield 87.8%.
According to the analysis of related databases, 57486-69-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Huazhong University of Science and Technology; Zhu Dajian; Li Tao; Chen Jian; Bi Jiajun; Meng Di; (7 pag.)CN107793323; (2018); A;,
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