In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 619-42-1 as follows. COA of Formula: C8H7BrO2
Step 1 Synthesis of 4-Phenylamino-benzoic acid methyl ester A mixture of Pd(OAc)2 (5 mg, 0.02 mmol), dicyclohexylphosphino-2′,3′-dimethoxy biphenyl (17 mg, 0.04 mmol) in toluene (20 mL) was purged with argon gas for 10 minutes, To the resulting mixture was added, aniline (136 mg, 1.46 mmol) and K3PO4(136 mg, 1.46 mmol) and purged with argon gas for 10 minutes and to which added 4-bromobenzoicacid methyl ester (300 mg, 1.4 mmol) and heated to reflux overnight. The reaction mixture was diluted with ethyl acetate and filtered the residue; the filtrate collected was concentrated under reduced pressure to afford the crude mass. The resultant mass was purified by column chromatography (using 60-120 silica gel and 10% EtOAc in Hexane as eluent) to afford 201 mg (63.4%) of 4-Phenylamino-benzoic acid methyl ester.
According to the analysis of related databases, 619-42-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bischoff, Alexander; Subramanya, Hosahalli; Sundaresan, Kumar; Sammeta, Srinivasa Raju; Vaka, Anil Kumar; US2010/160323; (2010); A1;,
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