In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7459-46-3 as follows. category: esters-buliding-blocks
To a solution of compound 30 (495 g, 2.01 mol) in tert-butanol (4 L) was added NaBH4 (434 g, 12.04 mol) with vigorous stirring at RT under N2 atmosphere. To this stirred solution was added methanol (250 mL) in three portions during 45 mins maintaining a gentle reflux. The reaction mixture was slowly warmed to 80 °C and allowed to reflux at the same temperature for over night. The reaction mixture was cooled, added 5M hydrochloric acid to get pH = 7 (app). The mixture was filtered, the residue washed with ethanol (2 x 500 mL) and combined the organic layers. The solvent was removed under vacuum and the crude product was purified by column chromatography on silica gel (10percent methanol in chloroform) to give the title compound (160 g, 66percent). TLC: Chloroform/Methanol, 4: 1, Rf=0.2
According to the analysis of related databases, 7459-46-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MEDIVIR AB; WO2005/65689; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics