Related Products of 87661-20-9, The chemical industry reduces the impact on the environment during synthesis 87661-20-9, name is tert-Butyl cyclopropanecarboxylate, I believe this compound will play a more active role in future production and life.
To a solution of diisopropylamine (24.5 ml) in THF (300 ml) was added at -20 C n-butyllithium (1.6 M solution in hexane, 109 ml), the mixture was warmed to 0C for 30 min and cooled to -78 C. The solution was treated with a solution of cyclopropanecarboxylic acid tert-butyl ester (24.8 g, preparation described in St.W. Wright et al, Tetrahedron Lett. 38, 7345 1997) in THF (50 ml) and after stirring for 4 h at -78C a solution of (R)-2-methyl-propane-2-sulfmic acid [l-(2-fluoro-5-nitro-phenyl)-(E)-ethylidene]- amide (50.0g) in THF (50 ml) was added and stirring was continued for 4 h. The mixture was quenched with brine, extracted with ethyl acetate, the organic layer was dried and evaporated. The residue was purified by chromatography over silica using cyclohexane /ethylacetate (4: 1) to give 1 -[(S)- l-(2-fluoro-5-nitro-phenyl)- 1 -((R)-2-methyl-propane-2-sulfinylamino)-ethyl]- cyclopropanecarboxylic acid tert-butyl ester (17.3 g) as a pale brown oil. MS (ESI): m/z = 429.3 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl cyclopropanecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BANNER, David; HILPERT, Hans; MAUSER, Harald; MAYWEG, Alexander V.; ROGERS-EVANS, Mark; WO2011/70029; (2011); A1;,
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