Synthetic Route of 1195768-18-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1195768-18-3, name is Methyl 3-amino-2-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To tetrahydrofuran (37.5mL of a) in the 2-fluoro-3-aminobenzoate ( 15.0g, 88.7mmol, 1.0eq.) and saturated aqueous sodium bicarbonate (120mL), and added dropwise allyl chloroformate (12.75g, 106mmol, 1.19eq.).The reaction was slowly warmed to room temperature.When TLC showed complete reaction, it was poured into water (800mL) and extracted with ethyl acetate.Extract was dried over sodium sulfate, filtered, and concentrated under reduced pressure to provide an amber liquid form of methyl 3 – [(allyloxy) carbonyl] amino-2-fluoro-benzoate (24.8 g of, 100% yield)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-2-fluorobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Pulaixike Company; Zhang, Chao; Ibrahim, Prabha N; Nespi, Marika; Shi, Songyuan; Spevak, Wayne; Habets, Gaston G; Burton, Elizabeth A; Hirth, Klaus-Peter; (181 pag.)CN105228983; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics