Synthetic Route of 6627-89-0, The chemical industry reduces the impact on the environment during synthesis 6627-89-0, name is tert-Butyl phenyl carbonate, I believe this compound will play a more active role in future production and life.
t-Butyl phenyl carbonate (20 mL, 0.11 mole) was added drop-wise to a solution of N-(3-aminopropyl)-1,3-propanediamine (0.05 mole) in anhydrous DMF (50 mL). To this solution was added Et3N (5 mL). The resulting mixture was stirred at room temperature overnight. The mixture was poured into a phosphate buffer (2 L, 0.025 M K2HPO4 and 0.025 M NaH2PO4), and the resulted solution was adjusted to pH 3 with 2 M H2SO4 with vigorous stirring. The mixture was extracted with DCM (2×250 mL) and the organic extracts were discarded. The aqueous layer was basified with aq. 9 N NaOH; and then was extracted with DCM (3×250 mL). The organic extracts were dried over Na2SO4, concentrated under reduced pressure, and then dried under vacuum overnight to give the desired product (15 g, 90% yield). Di-t-butyloxy Triamine (III):To a solution of triamine (II) (0.05 mole) in DMF (50 mL) was added the t-butyl phenyl carbonate (2.3 eq.). The reaction mixture was stirred overnight at room temperature and poured into phosphate buffer (1 L of 0.05 M K2HPO4 and 0.05 M NaH2PO4). The pH was adjusted to 3 with 2 M H2SO4 and extracted with diethyl ether (3×250 mL). The aq. phase was made strongly alkaline with 10 N NaOH and extracted with DCM (4×250 mL). The organic phase was washed with brine, dried over sodium sulphate, and concentrated under reduced pressure to provide the bis protected triamine (III) as a white solid (yield 60%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl phenyl carbonate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Affymax, Inc.; US2009/48147; (2009); A1;,
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