Electric Literature of 88709-17-5, The chemical industry reduces the impact on the environment during synthesis 88709-17-5, name is Ethyl 2-ethoxy-4-methylbenzoate, I believe this compound will play a more active role in future production and life.
Under an atmosphere of nitrogen, n-butyllithium (50 ml, 15% w/w solution in hexane) was added to a solution of diisopropylamine (7.25 g) in tetrahydrofuran (90 ml) at -30 C. The mixture was stirred at -30 C. for 30 minutes, cooled to -75 C., and 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU, 30 ml), was added slowly. A solution of ethyl 2-ethoxy-4-methylbenzoate (10 g) in tetrahydrofuran (10 ml) was then added at -75 C. and the mixture was stirred for two hours. Carbon dioxide gas was then purged into the reaction mixture at -75 C. till complete decolorization. The reaction mixture was then brought to room temperature, diluted with water (100 ml), and extracted with dichloromethane (100 ml). The aqueous layer was acidified with 10% aqueous sulphuric acid to pH 1.95 and extracted with toluene. The combined toluene layer was washed with water and concentrated in vacuo. Crystallisation with ethyl acetate/petroleum ether afforded (3-ethoxy-4-ethoxycarbonyl)-phenyl acetic acid 7.2 g (59.5%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-ethoxy-4-methylbenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Banbaxy Laboratories Limited; US6686497; (2004); B1;,
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