Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5616-81-9, name is tert-Butyl 2-(methylamino)acetate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 5616-81-9
Example 14 tert-butyl 2-((chlorocarbonyl)(methyl)amino)acetate (12) A solution of sarcosine tert-butyl ester hydrochloride 11 (4.214 g, 23.20 mmol) in CH2Cl2 (40 mL) was shaken with saturated NaHCO3 in a separatory funnel. The organic phase was dried over MgSO4 and concentrated to a clear oil (2.298 g, 68% yield). A solution of phosgene in toluene (20%, 10.9 mL, 23.75 mmol) was cooled to -25 C., and a solution of sarcosine tert-butyl ester (2.298 g, 15.78 mmol) and DIEA (5.5 mL, 31.66 mmol) in CH2Cl2 (10 mL) was introduced in a dropwise fashion. The solution was allowed to warm to rt over 1 hr, and was then washed with 1N HCl (50 mL) and EtOAc sufficient to form two layers was added. The organic phase was washed with water, then brine, and dried over MgSO4. This solution was used without further manipulation.
According to the analysis of related databases, 5616-81-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wood, Richard Delarey; McLeod, Rima; Mui, Ernest; Fomovska, Alina; Welsh, William; US2013/324555; (2013); A1;,
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