Synthetic Route of 35450-36-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35450-36-3, name is Methyl 2-bromo-5-methoxybenzoate, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of Cs2CO3 (2 mmol) in H2O (5 mL) were added methyl 2-bromobenzoate (1a, 1 mmol), 1H-pyrazol-5-amine (2a, 1.2 mmol), and CuI (0.2 mmol). The mixture was stirred at 100 C under nitrogen atomasphere until a complete conversion as indicated by TLC. It was cooled to room temperature and then extracted with ethyl acetate. The combined organic phase was dried over anhydrous Na2SO4, and concentrated under vacuum. The crude product was purified by column chromatography eluting with petroleum ether/ethyl acetate (3:1) to give 3a. Products 3b-3t and 6 were obtained in a similar manner.
The chemical industry reduces the impact on the environment during synthesis Methyl 2-bromo-5-methoxybenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Article; Zhang, Xinying; Gao, Lin; Wang, Zhangxin; Fan, Xuesen; Synthetic Communications; vol. 45; 21; (2015); p. 2426 – 2435;,
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