In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C4H7ClO4S
7V-(3-Methyl-benzo[Z>]thiophen-2-yl)-2-carbomethoxy-ethanesulfonamide (600-A).; A solution of compound 757-A (1.0 g, 5.01 mmol) and pyridine (851 muL, 10.5 mmol) in dichloromethane (20 mL), cooled to 10 0C was treated with 3- chlorosulfonyl-propionic acid methyl ester (716 muL, 5.25 mmol) and stirred at ambient temperature for 18 h. The solvent was evaporated in vacuo, and the crude residue purified by flash column chromatography (SiO2), eluting with an ethyl acetate (10- 50%) in heptane gradient to afford 1.1 g of compound 600-A as an off white solid. 1H- NMR (DMSO-fe): delta 2.31 (s, 3H), 2.82 (t, 2H), 3.43 (t, 2H), 3.62 (s, 3H), 7.24-7.50 (m, 2H), 7.58-7.77 (m, IH), 7.80-7.95 (m, IH), 10.17 (s, IH); MS: m/z 314.1 (MH+).
The synthetic route of 15441-07-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2009/12430; (2009); A1;,
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