In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36692-49-6, name is Methyl 3,4-diaminobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 36692-49-6
Example 21: 3-Amino-6-{4-[2-hydroxy-2-(2-phenyl-lN-benzoimidazol-5-yl)- ethylamino]-piperidin-1-yl}-4-propyl-thieno [2, 3-b] pyridine-2-carboxylic acid amide 0 0 o H i I so) Hunig’s base N -ire NH DCM 0 NH2 NH2 acetic acid H H THF / N N H min02 Mn02 N THE zon H 21 3,4-Diamino-benzoic acid methyl ester (2 g, 12.035 mmol) was dispersed in 40 mL DCM. Added hunig’s base (2.516 mL, 14.442 mmol) and stirred at RT until everything was in solution. Added benzoyl chloride (1.397 mL, 12.035 mmol) dropwise into the mixtuxe and stirred at RT for 1 hour. Added sat. NaHC03 aq. solution into the reaction mixture. Extracted with DCM three times. Combined all organic extracts and washed with brine. Dried over Na2SO4. Filtered and removed solvent in vacuo. Purified by flash chromatography using 10 % MeOH/DCM as eluent mixtures. 4-Amino-3-benzoylamino- benzoic acid methyl ester was trituated in hot ethyl acetate and 1.667 g (51.2 %) white solid was obtained.
The synthetic route of 36692-49-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2005/56562; (2005); A1;,
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