Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35613-44-6, name is Methyl 2-(2-aminophenyl)acetate, A new synthetic method of this compound is introduced below., SDS of cas: 35613-44-6
Preparation of 1 -(1 -(i-methyl-i ,2-dihydroacenaphthylen- 1 -yl)piperidin-4-yl)indolin-2- one (Compound 23-10)[00381j To a solution of 1 -(i-methyl-i ,2-dihydroacenaphthylen- 1 -yl)piperidin-4-one Compound 23-9 (132.68 mg, 0.5 mmol) and methyl 2-(2-aminophenyl)acetate (247.49 mg, 1.5 mmol) in 15 mL of dichioromethane was added acetic acid (150.0mg, 2.5 mmol). The mixture was stirred for 1.5 h at room temperature. Sodium triacetoxyborohydride (316.5 mg, 1.5 mmol) was added into the mixture and stirred2 h at room temperature. Then the reaction mixture was heated to 30C and stirred overnight. The mixture was washed with water (20 mL x 2), and sat. sodium carbonate (20 mL x 2), brine (20 mL x 2). The organic layer were dried over anhydrous sodium sulfate and evaporated in vacuum to afford the crude product. The crude product was purified by silica gel chromatography (ethyl acetate: petroleum ether = 1: 5 to 1: 2) to obtain 1 -(1 -(1-methyl-i ,2-dihydroacenaphthylen- 1 -yl)piperidin-4-yl)indolin-2- one(Compound 23-10, 101.5 mg, yield 53 %) as a white solid. ESIMS (mlz): 382 [M+H].
The synthetic route of 35613-44-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FANG, Qun, Kevin; SPEAR, Kerry, L.; CAMPBELL, Una; WO2014/106238; (2014); A1;,
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