In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 148547-19-7 as follows. category: esters-buliding-blocks
The compound 120a (1.0 g, 4.365 mmol) was dissolved in 1,4-dioxane (30 mL), and the compound 120b (2.22 g, 8.73 mmol), KOAc (1.5 g, 15.277 mmol), and PdCl2 were added. (dppf) (0.32 g, 0.436 mmol) and,Nitrogen was replaced three times, and then the reaction solution was stirred at 95 C for 16 hours. Cool to room temperature, add water (60 mL),Extracted with ethyl acetate (30 mL x 3), combined the organic layers and washed with water (30 mL x 2), dried over MgSO4, filtered and concentrated,The concentrate was purified by silica gel chromatography (ethyl acetate: petroleum ether = 0-10%) to obtain a white off-white compound 120c, 3-methyl-4- (4,4,5,5-tetramethyl-1, Methyl 3,2-dioxaborolan-2-yl) benzoate (1.113 g, yield 92.4%).
According to the analysis of related databases, 148547-19-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Jiaxing Tekeluo Biological Technology Co., Ltd.; Xing Li; Li Guanqun; Wang Xiaolei; Cai Yuting; Jiang Xiang; Pan Xiang; Zhu Wenhao; Wang Yang; Wang Zengquan; (83 pag.)CN110627775; (2019); A;,
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