Electric Literature of 2318-25-4, A common heterocyclic compound, 2318-25-4, name is Ethyl 3-ethoxy-3-iminopropionate hydrochloride, molecular formula is C7H14ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The imidate salt 2g2(1.4g, 7.2mmol, 1 eq.) was combined with 2-(methylthio)-aniline 211 (0.96g, 7.50mmol, 1 eq.) in ethanol (15 mL) under an N2 atmosphere. Thereaction mixture was stirred at R.T. (1 h) and monitored by HPLC. The reactionmixture was concentrated and then ether was added and the mixture filtered. Thesolids were washed with ether and the combined ether washes concentrated in vacuo.The resulting adduct 2I2 was obtained as a yellow oil (1.66g, 82percent) and used as is in the next step. MS electrospray: (M + H)+; 282 and (M – H)-; 280.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH & CO KG; WO2006/85; (2006); A1;,
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