Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 820236-81-5, name is Methyl 2-bromo-6-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H6BrFO2
Synthesis of methyl 2-[4-[2-[4-(2,2-dimethylpropyl)-1-trityl-imidazol-2-yl]ethyl]phenyl]-6-fluoro-benzoate (14): a mixture of 13 (5.17 g, 9.17 mmol), bis-pinacolatodiboron (3.06 g, 12.1 mmol), [1,1?-bis(diphenylphosphino)ferrocene]palladium(II) dichloride dichloromethane adduct (0.38 g, 0.47 mmol) and KOAc (2.74 g, 27.9 mmol) in dioxane (100 mL) was stirred under reflux for 8 h. After the reaction mixture was concentrated, the residue was dissolved in EtOAc and water, then filtered through a Celite pad. The organic layer was washed with brine, dried (Na2SO4), concentrated and purified by column chromatography (hexane:EtOAc = 5:1) to provide the boronate ester as a pale yellow solid (5.17 g, 92%). A mixture of the boronate ester (8.92 g, 14.6 mmol), methyl 2-bromo-6-fluoro-benzoate (4.42 g, 19.0 mmol), Pd(PPh3)4 (1.69 g, 1.46 mmol) and 2 M Na2CO3 (22 mL, 44 mmol) in DMF (170 mL) was stirred at 100 C for 7 h. The mixture was concentrated and diluted in ethylacetate, washed with water, dried (Na2SO4), concentrated and purified by column chromatography (hexane:EtOAc = 3:1) to provide 14 as a pale yellow amorphous (6.54 g, 71%) 1H NMR (CDCl3) delta: 7.43-7.36 (1H, m), 7.35-7.29 (9H, m), 7.16-7.10 (9H, m), 7.10-7.04 (1H, m), 6.84 (2H, d, J = 8.2 Hz), 6.35 (1H, s), 3.61 (3H, s), 2.45-2.40 (4H, m), 2.31-2.25 (2H, m), 0.93 (9H, s). MS (APCI) m/z: 637 (M+H)+.
According to the analysis of related databases, 820236-81-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kiyotsuka, Yohei; Shimada, Kousei; Kobayashi, Shozo; Suzuki, Masanori; Akiu, Mayuko; Asano, Masayoshi; Sogawa, Yoshitaka; Hara, Takashi; Konishi, Masahiro; Abe-Ohya, Rie; Izumi, Masanori; Nagai, Yoko; Yoshida, Kazuhiro; Abe, Yasuyuki; Takamori, Hideo; Takahashi, Hisashi; Bioorganic and Medicinal Chemistry Letters; vol. 26; 17; (2016); p. 4205 – 4210;,
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