In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 383-62-0 as follows. Quality Control of Ethyl 2-chloro-2,2-difluoroacetate
[0068] Synthesis of Compound B: A mixture of Compound A (3g, 1 eq), K2CO3 (3.06g, 2 eq), ethyl chlorodifluoroacetate(2.2g, 1.3 eq) in DMF (20 ml), was heated at 75C overnight. The reaction was monitored by TLC. After completion, themixture was poured into cold water (50 ml) and extracted with ethyl acetate (3350 ml). The combined organic layer waswashed with water (2330 ml), saline solution (20 ml) and dried over anhydrous sodium sulfate. Purification of the crudeproduct by column chromatography (10% ethyl acetate in hexane) yielded 1 g of the desired product. 1H NMR (DMSOd6)Theoretical MS for C17H11F3NO3: 320.26; M++ 1 found, 321.1
According to the analysis of related databases, 383-62-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Artax Biopharma Inc.; GAGETE MATEOS, Andres; CASTRO PALOMINO, Julio; MARTI CLAUZEL, Luc; TORMO CARULLA, Damia; (23 pag.)EP3059232; (2016); A1;,
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