Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1236357-65-5, name is Methyl 1-(4-bromophenyl)cyclobutanecarboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 1-(4-bromophenyl)cyclobutanecarboxylate
Methyl 1-(4-bromophenyl)cyclobutanecarboxylate under nitrogen atmosphere(1.3 g, 4.8 mmol), (R)-3-oxo hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylic acid tert-butyl ester (1.2 g, 4.8 mmol),Tris(dibenzylideneacetone)dipalladium(440mg, 0.48mmol),2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (410 mg, 0.97 mmol) and cesium carbonate (3.1 g, 9.5 mmol) were dissolved.In 1,4-dioxane (30 mL). The reaction was carried out at 90 C for 12 h.The heating was stopped, the solid was filtered off, and the filtrate was concentrated under reduced pressure.The residue obtained was subjected to silica gel column chromatography(PE/EA(V/V)=4/1)Purified to give the title compound as a white solid(770 mg, 37%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Liu Xinchang; Huang Jianzhou; Zhang Yingjun; S ·geerdeman; (267 pag.)CN109111451; (2019); A;,
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