Application of 53518-15-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53518-15-3 name is 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A vial was charged with S5 (9 mg, 0.011 mmol), 7-amino-4-(trifluoromethyl) coumarin (7 mg, 0.033 mmol, 3 eq.), HATU (12 mg, 0.033 mmol, 3 eq.), DIEA (19 1iL, 0.11 mmol, 10 eq.) and DIvIF (300 1iL). Contents were stirred at room temperature and ambient atmosphere for 24 h, after which the solvent was concentrated to dryness, and the crude product was purified by silica gel chromatography (0-5% MeOH/DCM, linear gradient) to afford PC-3F549-exHT (2 mg, 18%).?H NMR (CDC13, 400 MHz) 8.05 (d, J 7.9 Hz, 1H), 7.92 (d, J= 8.0 Hz, 1H), 7.49 (m, 2H), 7.30 (dd, J 8.9, 2.1 Hz, 1H), 7.17 (d, J= 2.1 Hz, 111), 6.79 (s, 1H), 6.65 (s, 1H), 6.57 (d, J 8.6 Hz, 2H), 6.12 (d, J 2.3 Hz, 2H), 6.02 (dd, J= 8.6, 2.3 Hz, 2H), 5.23 (s, 1H), 4.14 (s, 2H), 3.89 (t, J 7.3 Hz, 811),3.67 -3.50 (m, 18H), 3.45 (t, J 6.6 Hz, 211), 3.33 (d, J= 5.6 Hz, 2H), 2.37 (p, J= 7.2 Hz, 4H),1.77 (p,J= 6.7 Hz, 2H), 1.60 (d, J= 14.6 Hz, 2H), 1.44 (q, J 8.1, 6.8 Hz, 2H), 1.37 (d, J 7.0 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one, and friends who are interested can also refer to it.
Reference:
Patent; HOWARD HUGHES MEDICAL INSTITUTE; LAVIS, Luke; JRADI, Fadi, M.; (109 pag.)WO2018/182811; (2018); A1;,
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