Electric Literature of 31600-43-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31600-43-8 as follows.
[00459] Methyl 2-(benzyloxy)acetate (112) (5.5 g, 30.6 mmol) was dissolved in THF (30 mL). LiAlD4 (1.4 g, 35 mmol) was added at 0 C and the reaction mixture was stirred for 3 h. Water (1.4 mL) was added to quench the reaction. 10% aqueous NaOH solution (2.8 mL) and water (4.2 mL) were added. The mixture was filtered through a pad of CELITE, and the precipitate was washed with THF. The filtrate was dried over anhydrous Na2S04, and concentrated to give crude product, which was purified by silica gel chromatography (30% EtO Ac/petroleum ether) to obtain 2-(benzyloxy)-l,l-dideuteroethanol (113) Yield (3.4 g, 74%). LCMS: m/z 177.1 [M+Na]+; tR = 1.40 min.
According to the analysis of related databases, 31600-43-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KARYOPHARM THERAPEUTICS INC.; BALOGLU, Erkan; SHACHAM, Sharon; SENAPEDIS, William; MCCAULEY, Dilara; LANDESMAN, Yosef; GOLAN, Gali; KALID, Ori; SHECHTER, Sharon; WO2015/42414; (2015); A1;,
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