These common heterocyclic compound, 369-26-6, name is Methyl 3-amino-4-fluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Methyl 3-amino-4-fluorobenzoate
To a solution of imidazo[1 ,2-a]pyridine-3-carboxylic acid (1 ) (10 g, 61 .73 mmol) in dichloromethane (300 ml_) was added DMF (2 ml_) and oxalyl chloride (18 g, 141 .73 mmol) at 0-10 °C. The resulting solution was stirred overnight at room temperature and concentrated under vacuum. The solid obtained was added into a solution of methyl 3- amino-4-fluorobenzoate (7) (10 g, 59.17 mmol) and TEA (20 g, 198.02 mmol) in dichloromethane portionwise. The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under vacuum and diluted with of methanol (250 ml_). The solids were collected by filtration and washed with sat. Na2C03 (2×200 ml_) and methanol (2×50 ml_) to yield methyl 4-fluoro-3-(imidazo[1 ,2-a]pyridine-3- carboxamido)benzoate (8) as a light yellow solid.
The synthetic route of Methyl 3-amino-4-fluorobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IRM LLC; NOVARTIS PHARMACEUTICALS UK LIMITED; LIANG, Fang; GIBNEY, Michael; YEH, Vince; LI, Xiaolin; MOLTENI, Valentina; SHAW, Duncan; BERMAN, Ashley Mitchell; LEWIS, Sarah; LOREN, Jon; FURMINGER, Vikki; WO2013/33620; (2013); A1;,
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