Simple exploration of Methyl 4-bromo-2,6-difluorobenzoate

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 773134-11-5, name is Methyl 4-bromo-2,6-difluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Methyl 4-bromo-2,6-difluorobenzoate

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 773134-11-5, name is Methyl 4-bromo-2,6-difluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Methyl 4-bromo-2,6-difluorobenzoate

Step 2 : Methyl 4-bromo-2-fluoro-6-iiitrometh lbenzoate To a 50 mL flask is added nitromethane (1.0 mL, 16.9 mmol), anhydrous magnesium sulfate (4.0 g), DMSO (15 mL), and in portion sodium hydride (405 mg, 16.9 mmol). After 30 min, methyl 4-bromo-2,6-difluorobenzoate (530 mg, 2.1 mmol) is added. After stirring for 2 days, water (80 mL) and aqueous hydrochloric acid (6 M, 50 mL) are added, followed by dichloromethane (100 mL). The aqueous layer is separated and extracted with dichloromethane (2 X 50 mL). The combined organic phases are washed with brine (50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue is purified on a silica gel flash chromatography with ethyl acetate/petroleum ether (1 :30) to provide the titled compound as a light yellow solid (270 mg, 44% yield). ( MS: [M+l] 292)

The synthetic route of 773134-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng; WO2014/32498; (2014); A1;,
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