Application of 4630-80-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4630-80-2 as follows.
To a suspension of NaH (2.75 g, 68.7 mmol) in THF (15 ml_) at 700C was added dropwise a solution of methyl cyclopentanecarboxylate (8.00 g, 62.4 mmol) and anhydrous acetonitrile (3.91 ml_, 74.9 mmol) in THF (5 ml_). The mixture was stirred for 16 h at 70C-72C, cooled to rt, and diluted with ethyl acetate and aqueous HCI. The organic layer was washed successively with water and brine and dried (MgSO4), filtered and concentrated under reduced pressure to provide the title compound, which was used without further purification.
According to the analysis of related databases, 4630-80-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2007/64872; (2007); A2;,
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