In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C9H9BrO2
To a stirred solution of 100 g methyl-(4-bromophenyl)acetate(9, 0.436 mol) in 300 cm3 tetrahydrofuran, 95 g sodium methoxide (1.75 mol) was added at 0-5 C and maintained for 1 h. 80 g dimethyl carbonate (0.88 mol)was added at 0-5 C over a period of 2 h. The reaction mass was maintained at 25-30 C until the completion ofthe reaction (monitored by HPLC). After completion of the reaction, tetrahydrofuran was concentrated under reduced pressure at 45 C to obtain the syrup. The syrup was diluted in 500 cm3 water and the product was extracted in250 cm3 dichloromethane. The organic layer was concentrated under reduced pressure at 45 C to obtain the thick solution which was dissolved in 200 cm3 isopropyl alcoholat 70 C and maintained for 1 h. The solution was cooled to 0 C and maintained for 60 min. The obtained solid was filtered, washed with isopropyl alcohol, and dried at 50-55 C for 4-6 h to provide 10. Yield: 80 g; purity by HPLC: 99%; m.p.: 72-76 C. The spectral data of compound 10 were found to agree with the reported data [8].
The synthetic route of 41841-16-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jagtap, Kunal M.; Niphade, Navnath C.; Gaikwad, Chandrashekhar T.; Shinde, Gorakshanath B.; Toche, Raghunath B.; Joshi, Divyesh R.; Mathad, Vijayavitthal T.; Monatshefte fur Chemie; vol. 149; 3; (2018); p. 653 – 661;,
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