Reference of 106685-41-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 106685-41-0 as follows.
A round-bottom flask is loaded with adapalene methyl ester (7 g; 16.41 mmol), THF (42 ml), water (7 ml) and a 50% w/w sodium hydroxide aqueous solution (1.44 g; 18.05 mmol). The mixture is refluxed for 6 hours, then added with water (133 ml) and THF is distilled off to a residual content of approx. 5% w/w, heated to a temperature of about 80C until complete dissolution of the solid, then cooled to 15C. The crystallized product is filtered and dried under vacuum in a static dryer at a temperature of 50C, thereby obtaining adapalene sodium salt (6.7 g; 15.42 mmol) in 94% yield.
According to the analysis of related databases, 106685-41-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Dipharma S.p.A.; Lundbeck Pharmaceuticals Italy S.P.A.; EP1707555; (2006); A1;,
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