Related Products of 13831-03-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13831-03-3 as follows.
To the mixture of methyl 3-iodobenzoate (157 mg, 0.60 mmol), K2CO3 (166 mg, 1.20 mmol), cupper(I) iodide (14 mg, 0.07 mmol) and PdCl2(Ph3P)2 (21 mg, 0.03 mmol) in tetrahydrofuran (2 mL) was added tert-butyl propiolate (16) (330 mL, 2.40 mmol) at room temperature. After stirred for 20 h at 60C, the mixture was evaporated to dryness. The residue was chromatographed on a silica gel (AcOEt:hexanes=0:1~1:10) to give tert-butyl 3-(3-(methoxycarbonyl)phenyl)propiolate (17b) (155 mg, 99% yield) as light brown oil. 1H NMR (300 MHz, CDCl3) delta 8.25 (t, J = 1.4, 1H), 8.16 – 8.05 (m, 1H), 7.80 – 7.68 (m, 1H), 7.46 (t, J = 7.8, 1H), 3.93 (s, 3H), 1.55 (s, 9H).
According to the analysis of related databases, 13831-03-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kawate, Tomohiko; Iwase, Noriaki; Shimizu, Motohisa; Stanley, Sarah A.; Wellington, Samantha; Kazyanskaya, Edward; Hung, Deborah T.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 22; (2013); p. 6052 – 6059;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics