Reference of 50413-30-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50413-30-4 as follows.
To a stirred solution of compound If-I (7 g, 38.6 mmol) in pyridine (80 ml) was slowly added TsCI (8.8 g, 46.6 mmol) at rt. This solution was further stirred for 16h. The reaction mixture was poured into cold water upon which a solid was formed. The precipitate was filtered off and washed with n-pentane (50 ml) to afford the title compound If-2 as an off-white solid (10.8 g, 70% yield). LCMS [M+H] 336.
According to the analysis of related databases, 50413-30-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; MAMAI, Ahmed; (134 pag.)WO2019/119141; (2019); A1;,
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