In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28868-76-0, name is Dimethyl 2-chloromalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Dimethyl 2-chloromalonate
To 8.33 g of dimethyl chloromalonate, 10.7 ml of 7N ammonia/methanol solution was dropped at 0C and then stirred for 10 minutes. The reaction mixture was further stirred at room temperature for 2 hours, filtered and concentrated. The residue was dissolved with a mixed solvent of chloroform with methanol. The solution was filtered, and then concentrated. The residue was subjected to silica gel column chromatography to give 4.4 g of methyl 2-chloro-2-carboxamideacetate. Mp. 79.5C1H-NMR (300 M Hz, CDCl3, TMS delta (ppm) ) : 3.86 (s, 3H), 4.79 (s, 1H), 5.8-6.0 (bs, 1H), 6.5-6.7 (bs, 1H)
The synthetic route of 28868-76-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sumitomo Chemical Company, Limited; EP1422227; (2004); A1;,
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