Reference of 61367-07-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61367-07-5, name is Methyl trans-4-aminocyclohexanecarboxylate hydrochloride belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(3) A suspension of the compound obtained in the above step (2) (10 g), 1,5-diiodopentane (9.2 mL) and sodium carbonate (16.4 g) in tetrahydrofuran (300 mL)/N,N-dimethylacetamide (60 mL) was stirred at 70 C for 20 hours. The reaction mixture was concentrated in vacuo and the residue was dissolved in ethyl acetate/water. The organic layer was separated and washed successively with water and brine, dried over sodium sulfate and concentrated in vacuo. The resultant residue was purified by a column chromatography on NH-silica gel (Solvent; ethyl acetate/n-hexane = 1: 5) to give methyl trans-4-(1-piperidyl)cyclohexanecarboxylate (10.17 g). MS(APCI)m/z; 226 [M+H]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl trans-4-aminocyclohexanecarboxylate hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; EP1772454; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics