Adding a certain compound to certain chemical reactions, such as: 154825-97-5, name is Methyl 2-(4-bromophenyl)-2,2-dimethylacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 154825-97-5, Application In Synthesis of Methyl 2-(4-bromophenyl)-2,2-dimethylacetate
To a suspension of lithium aluminum hydride (2.95 g, 78 mmol, 2 equiv.) in THF (70 mL) at 0C was added a solution of methyl 2-(4-bromophenyl)-2-methylpropanoate (10 g, 39 mmol, 1 equiv.) in THF (60 mL) dropwise. After stirring at 0C for 1 h, the reaction was quenched sequentially with 3 mL of water, 9 mL of a 5% sodium hydroxide solution and 3 mL of water. It was filtered on a Celite pad using ether as an eluent. The solvent was evaporated and the residue was purified by bulb-to-bulb distillation (2-4 mbar, l30C) to afford 2-(4-bromophenyl)-2-methylpropan-l-ol (8.27 g, 93% yield).1H NMR: 1.30 (s, 6H), 3.57 (s, 2H), 7.25 (d, J = 8.6 Hz, 2H), 7.45 (d, J = 8.6 Hz, 2H).13C NMR: 145.6 (s), 131.4 (d, 2C), 128.2 (d, 2C), 120.1 (s), 72.8 (t), 39.9 (s), 25.2 (q,2C).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-(4-bromophenyl)-2,2-dimethylacetate, and friends who are interested can also refer to it.
Reference:
Patent; FIRMENICH SA; COULOMB, Julien; ODDON, Gilles; (33 pag.)WO2019/141761; (2019); A1;,
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