Electric Literature of 139102-34-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139102-34-4 name is Methyl 4-bromo-2-methoxybenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under the protection of nitrogen,Compound 46C (232 mg, 1 mmol),Methyl 4-bromo-2-methoxybenzoate (257 mg, 1.05 mmol),Palladium acetate (22.5 mg, 0.1 mmol), BINAP (62.5 mg, 0.1 mmol),The 1,4-dioxane solution of cesium carbonate (489 mg, 1.5 mmol) was heated to 110 C for 4 hours, then cooled to room temperature, quenched with aqueous solution, filtered, and extracted with ethyl acetate.Dry with anhydrous sodium sulfate,The compound was quenched under reduced pressure to give compound 46D (158 mg, 40% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-bromo-2-methoxybenzoate, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Cao Wenjie; Zhang Guiping; Zhao Zhongqiang; Jiang Zhaojian; Zuo Gaolei; Xu Wanmei; Gong Hongju; Zhang Peng; Wang Jianghuai; Li Qingsong; Gao Chunhua; (79 pag.)CN104045552; (2019); B;,
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