Application of 57267-03-5,Some common heterocyclic compound, 57267-03-5, name is Ethyl 2,2,2-triethoxyacetate, molecular formula is C10H20O5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Ethyl 2,2,2-triethoxyacetate (221.9 mg, 1.02 mmol) was added dropwise to a solution of (s)-tert-butyl (1 -((2?,3 ?-diamino-3 -(N,N-bis(4-methoxybenzyl)sulfamoyl)-2-(2-(4- methoxybenzyl)-2H-tetrazol-5 -yl)-[ 1,1 ?-biphenyl] -4-yl)sulfonyl)propan-2-yl)carbamate (300 mg, 0.328 mmol) in EtOH (5 ml) at 0C. The mixture was evacuated and backfilled with nitrogen 3 timesand stirred at 80C for l6hr. The reaction progress was monitored by LCMS. When the reaction was completed, it was concentrated under vacuum. The residue was applied on a silica gel column with EA/PE(1/1) to give the title compound as a solid.: LCMS (ESI) calc?d for C49H54N801152 [M + H]: 995, found 995.
The synthetic route of 57267-03-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BENNETT, Frank; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; SCOTT, Jack D.; TANG, Haiqun; ZHAO, Zhiqiang; HUANG, Yuhua; HUNTER, David; YANG, Dexi; ZHANG, Zhibo; FU, Jianmin; BAI, Yunfeng; ZHENG, Zhixiang; ZHANG, Xu; YOUNG, Katherine; XIAO, Li; (580 pag.)WO2016/206101; (2016); A1;,
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