Adding a certain compound to certain chemical reactions, such as: 252881-74-6, name is tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 252881-74-6, Computed Properties of C13H27NO5
To a solution of 5-hexynoic acid (100 mg, 893 mumol), WSC (257 mg, 1.34 mmol),HOBt (205 mg, 1.34 mmol) and DIPEA (622 muL, 3.60 mmol) in dry DMF (2 mL) wasadded tert-butyl-12-amino-4,7,10-trioxadodecanoate (297 mg, 1.34 mmol). The reactionmixture was stirred for 19 h at room temperature. After evaporation under reducedpressure, the reaction mixture was diluted in AcOEt and washed with sat NaHCO3 aq.,water and brine, and dried over Na2SO4. After filtration and evaporation gave compound3-5 (313 mg, 0.84 mmol, 68%) as a colorless oil.
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Reference:
Article; Takaoka, Yousuke; Uchinomiya, Shohei; Kobayashi, Daichi; Endo, Masataka; Hayashi, Takahiro; Fukuyama, Yoshiaki; Hayasaka, Haruko; Miyasaka, Masayuki; Ueda, Takumi; Shimada, Ichio; Hamachi, Itaru; Chem; vol. 4; 6; (2018); p. 1451 – 1464;,
Ester – Wikipedia,
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