Introduction of a new synthetic route about Methyl 2-amino-3-methoxybenzoate

Electric Literature of 5121-34-6, These common heterocyclic compound, 5121-34-6, name is Methyl 2-amino-3-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Electric Literature of 5121-34-6, These common heterocyclic compound, 5121-34-6, name is Methyl 2-amino-3-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of compound 53 (22.4 g 123 mmol) in DMF (250 mL) was added N-bromosuccinimide (21.9 g, 123 mmol) portionwise at 0 C. The mixture was stirred at 0 C for 0.5 h. To the mixture was added water and extracted with EtOAc (500 mL x 2). The combined organic layer was dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography to provide the desired compound 54 (27.5 g, 86%) as a white solid.

Statistics shows that Methyl 2-amino-3-methoxybenzoate is playing an increasingly important role. we look forward to future research findings about 5121-34-6.

Reference:
Patent; GREEN CROSS CORP.GREEN CROSS CORPORATION; CHOI, SOONGYU; SONG, KWANG-SEOP; LEE, SUK HO; KIM, MIN JU; SEO, HEE JEONG; PARK, EUN-JUNG; KONG, YOUNGGYU; PARK, SO OK; KANG, HYUNKU; JUNG, MYUNG EUN; LEE, KINAM; KIM, HYUN JUNG; LEE, JUN SUNG; LEE, MIN WOO; KIM, MI-SOON; HONG, DONG HO; KANG, MISUK; (278 pag.)JP5876570; (2016); B2;,
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