Electric Literature of 25542-62-5, These common heterocyclic compound, 25542-62-5, name is Ethyl 6-bromohexanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 50-mL round bottom flask, a stuffed solution of substituted 5-bromo-2-hydroxybenzaldehyde(5.0 g, 24.8 mmol) in DMF (30 mL), was treated with potassium carbonate (10.26g, 74.4 mmol) and ethyl 6-bromohexanoate (6.6g, 29.8 mmol) at rt under nitrogen atmosphere. The reaction mixture was heated at 90C for 4 h. Upon completion of the reaction (TLC) the reaction mixture was cooled to rt, diluted with cold water and extracted ethyl acetate (250 mL x 2). The combined organic extract was washed with brine and dried over anhydrous Na2SO4. The solution was concentrated under reduced pressure to give the titlecompound (7.97 g, 94%) as yellow oil. LCMS (m/z): 343.2 (M+1).
Statistics shows that Ethyl 6-bromohexanoate is playing an increasingly important role. we look forward to future research findings about 25542-62-5.
Reference:
Patent; SALK INSTITUTE FOR BIOLOGICAL STUDIES; EVANS, Ronald, M.; DOWNES, Michael; (258 pag.)WO2016/57322; (2016); A1;,
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