Related Products of 75567-84-9, The chemical industry reduces the impact on the environment during synthesis 75567-84-9, name is Methyl 3-(4-bromophenyl)propanoate, I believe this compound will play a more active role in future production and life.
(Example 65) 3-(4′-{[2-(tert-Butoxycarbonyl)-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-1,1′-biphenyl-4-yl)propanoic acid (Exemplification Compound No.: 1-67) According to a method similar to Example (31) and Example (17-4), from methyl 3-(4-bromophenyl)propionate (131 mg, 0.51 mmol) and tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate (250 mg, 0.51 mmol) obtained in Example (22-4), the title compound was obtained as a colorless powder (26 mg, yield: 10%). 1H-NMR (400MHz, DMSO-d6): delta 12.09 (1H, br), 11.40 (1H, br), 7.79 (1H, d, J = 7.8 Hz), 7.58 (2H; d, J = 8.6 Hz), 7.50 (2H, d, J = 8.6 Hz), 7.28-7.24 (3H, m), 7.03 (2H, d, J = 8.6 Hz), 5.35 (2H, s), 2.83 (2H, t, J = 7.8 Hz), 2.55 (2H, t, J= 7.8 Hz), 1.56 (9H, s). MS (FAB+) (m/z): 516 (M+.).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-(4-bromophenyl)propanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Daiichi Sankyo Company, Limited; EP1806332; (2007); A1;,
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