Synthetic Route of 3697-68-5, The chemical industry reduces the impact on the environment during synthesis 3697-68-5, name is Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate, I believe this compound will play a more active role in future production and life.
To a solution of ethyl l-(hydroxymethyl)cyclopropane-l-carboxylate (3.0 g, 21 mmol) in DCM (50 mL) at -10 C was added DAST (6.0 g, 40 mmol) under Ar. The reaction mixture was stirred as it warmed to ambient temperature over 1 h and continued to stir at that temperature for 23 h. An aqueous solution of HC1 (10%, 5 drops) and H20 (50 mL) were added, and the layers were separated. The aqueous layer was extracted with DCM (50 mL) and the combined organic phases were washed sequentially with H20 (50 mL) and brine (50 mL), dried (MgS04), and filtered. The filtrate was concentrated in vacuo to give ethyl l-(fluoromethyl)cyclopropane-l- carboxylate (3.0 g, yield:99%), which was carried forward without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BIOGEN MA INC.; HOPKINS, Brian, T.; MA, Bin; PRINCE, Robin; MARX, Isaac; SCHULZ, Juergen; NEVALAINEN, Marta; DECHANTSREITER, Michael; (273 pag.)WO2019/222101; (2019); A1;,
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