Reference of 431-47-0,Some common heterocyclic compound, 431-47-0, name is Methyl 2,2,2-trifluoroacetate, molecular formula is C3H3F3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Propargyl amine (4.00 g, 72.62 mmol, 1.00 equiv.) was added dropwise to methyl trifluoroacetate (11.16 g, 87.15 mmol, 1.20 equiv.) at 0C. The reaction mixture was stirred at 0C for 2 h and then concentrated under reduced pressure to remove methanol. The product was purified by vacuum distillation yielding propargyltrifluoroacetamide as a colorless liquid (9.59 g, 87 %). The structure was confirmed by 1H- and 19F-NMR.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2,2,2-trifluoroacetate, its application will become more common.
Reference:
Patent; Pierce Biotechnology, Inc.; Etienne, Christopher; Opperman, Kay; Kaboord, Barbara; Meier, Scott; Schultz, Jean-Samuel; EP2669291; (2013); A1;,
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